NCT01528514

Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study

The Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Wanwarang Wongcharoen, MD. · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

It is well-established that myocardial infarction (MI) associated with coronary artery bypass graft surgery (CABG) predicts the poor outcome. Nevertheless, the cardioprotective therapies to limit myocardial injury after CABG are lacking. Previous studies have shown that curcuminoids suppress pro-inflammatory cytokines during cardiopulmonary bypass surgery and decrease the occurrence of cardiomyocytic apoptosis after cardiac ischemia/reperfusion injury in animal models. The investigators aim to evaluate whether curcuminoids prevent MI after CABG, compared to placebo.

Conditions

• Coronary Artery Bypass Grafting

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Curcuminoids	Curcuminoids in capsule form, 4 capsules four times daily (4 grams/day)
OTHER	Placebo	Placebo in capsule form, 4 capsules 4 times/day

Timeline

• Start date: 2009-09-01
• Primary completion: 2011-09-01
• Completion: 2012-12-01
• First posted: 2012-02-08
• Last updated: 2019-09-18

Locations

1 site across 1 country: Thailand