NCT01521650

Probiotics Against Pathogenic Bacteria in Connection With Anaesthesia

Probiotics for Reduction of Colonisation With Pathogenic Bacteria in the Oropharynx in Connection With Anaesthesia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Region Skane · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Longer surgical procedures require intubation and there is a potential risk of contaminating the lower airways with pathogenic bacteria from the mouth and oropharynx. Healthy people seldom have pathogenic bacteria originating from the gastro-intestinal canal but those do occur among patients, both in those not so sick and patients with more severe problems. For ICU patients we have seen a reduction of emerging enteric bacteria in patients given oral care with probiotics and this is a pilot study to explore the possibility of the same kind of positive effects in patients due for longer (more than 4 hours of anesthesia) procedures. Randomisation * No prophylaxis * Preparation with a probiotic suspension before intubation. Cultures * oropharynx * before treatment * after intubation * before extubation * day 1 postoperatively * tracheal secretions * after intubation * before extubation

Conditions

• Oropharyngeal Microbiology

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotics	Patients will gurgle and swallow a mixture of probiotic bacteria

Timeline

• Start date: 2012-01-01
• Primary completion: 2019-03-01
• Completion: 2020-07-01
• First posted: 2012-01-31
• Last updated: 2021-03-10

Locations

1 site across 1 country: Sweden