NCT01521195

Oxygen Consumption In Critically Ill Children

A Pilot Study of the Relationship Between Oxygen Delivery and Consumption During Extracorporeal Membrane Oxygenation.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: The Hospital for Sick Children · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators propose to examine the relationship between DO2 and VO2 in critically ill patients requiring an Extracorporeal Membrane Oxygenation (ECMO) machine. This machine can provide complete support of heart and lung function. In so doing, the investigators will be able to avoid physiologic coupling by increasing DO2 mechanically, by increasing blood flow through the ECMO circuit. Null Hypothesis: Increased oxygen delivery, by means of an increased rate of extracorporeal blood flow, is not associated with an increase in oxygen consumption. Alternate Hypothesis: Increased oxygen delivery, by means of an increased rate of extracorporeal blood flow, is associated with an increase in oxygen consumption.

Conditions

• Extracorporeal Membrane Oxygenation

Interventions

Type	Name	Description
DEVICE	Extracorporeal blood flow via ECMO machine	Extracorporeal Membrane Oxygenation (ECMO) machine can provide complete support of heart and lung function. Extracorporeal blood flow will be given at baseline rate, increased by 25% and decreased by 25%

Timeline

• Start date: 2011-10-01
• Primary completion: 2013-12-01
• Completion: 2014-02-01
• First posted: 2012-01-30
• Last updated: 2021-07-23

Locations

1 site across 1 country: Canada