NCT01520233

Gene Expression in Predicting Outcome in Samples From Patients With High-Risk Neuroblastoma

Genome Based Outcome Prediction in High Risk Neuroblastoma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in RNA and predict how patients will respond to treatment. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies gene expression in predicting outcomes in samples from patients with high-risk neuroblastoma.

Detailed description

OBJECTIVES: * To test the correlation of a previously published microarray gene expression signature with the gene expression obtained with the nCounter™ Analysis System using RNA isolated from formalin-fixed, paraffin-embedded (FFPE), high-risk neuroblastoma samples. * To construct, test, and validate a novel robust classifier that can be readily integrated into the clinic. OUTLINE: This is a multicenter study. RNA samples extracted from paraffin-embedded tissue are analyzed for gene signature expression levels by nCounter™ Analysis System and correlated with published microarray expression data. Results are then used to develop a refined gene-expression-profile classifier of ultra high-risk neuroblastoma.

Conditions

• Neuroblastoma

Interventions

Type	Name	Description
GENETIC	RNA analysis
GENETIC	gene expression analysis
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2012-01-01
• Primary completion: 2016-05-01
• Completion: 2016-05-01
• First posted: 2012-01-27
• Last updated: 2016-05-17