Trials / Completed
CompletedNCT01519726
CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug
CYP3A4 Metabolism Before and After Surgery Induced Weight Loss in Morbidly Obese Patients Using Midazolam as a Model Drug
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- Sponsor
- St. Antonius Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
Before and during bariatric surgery patients are given oral and i.v. midazolam, respectively and blood samples are drawn to establish midazolam time-concentration profiles. After 0.5-2 years, and substantial weight loss, oral and i.v. midazolam are administered once more and blood samples are taken again.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Midazolam |
Timeline
- Start date
- 2011-12-01
- Primary completion
- 2013-12-01
- Completion
- 2013-12-01
- First posted
- 2012-01-27
- Last updated
- 2019-04-04
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT01519726. Inclusion in this directory is not an endorsement.