NCT01519063

Naltrexone and Memantine Effects on Alcohol Drinking Behaviors

Glutamate-opioid Interactions in Alcohol Drinking Behaviors

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors.

Detailed description

Participants will be randomized to receive a combination of naltrexone/memantine over a one week period and then participate in a laboratory session. During this session, participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. These medications are hypothesized to reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period.

Conditions

• Alcohol Drinking

Interventions

Type	Name	Description
DRUG	Naltrexone and memantine first	Naltrexone 50mg memantine 20mg
DRUG	Naltrexone and Placebo first	Naltrexone 50 mg Placebo

Timeline

• Start date: 2012-01-01
• Primary completion: 2017-03-29
• Completion: 2017-05-01
• First posted: 2012-01-26
• Last updated: 2020-03-09
• Results posted: 2019-07-10

Locations

1 site across 1 country: United States