NCT01517490

Retinal Adaptation to Intensified Insulin Therapy and Bariatric Surgery in Patients With Diabetes

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Glostrup University Hospital, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Retinal function is highly dependent on the glucose supply. Thus, functional adaptations occur in response to both acute and long-term changes in glycaemia. The purpose of this study is to examine functional and metabolic aspects of retinal adaptation to long-lasting changes in glycaemic control in patients with diabetes. The adaptational phenomena will be characterized by electroretinography, dark adaptation, measures of retinal perfusion and oximetry as well as diabetic retinopathy grading and (OCT).

Conditions

• Diabetes Mellitus
• Diabetic Retinopathy

Interventions

Type	Name	Description
OTHER	Insulin pump	Insulin pump therapy
OTHER	Multiple daily insulin injections	Multiple daily insulin injections
PROCEDURE	Bariatric surgery	Pre-operative weight loss and bariatric surgery.
OTHER	Medical therapy for type 2 diabetes	Medical glucose-lowering therapy and non-surgical weight-lowering interventions.

Timeline

• Start date: 2011-08-01
• Primary completion: 2016-12-01
• First posted: 2012-01-25
• Last updated: 2015-03-11

Locations

1 site across 1 country: Denmark