NCT01513499

Effect of Intranasal Oxytocin on Appetite and Caloric Intake in Men and Women

Effect of Intranasal Oxytocin on Appetite and Caloric Intake in Humans

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Exciting advances have led to the concept that hormones can modulate appetite and food intake. Oxytocin is a peptide hormone that is released in regions throughout the brain, including areas involved in food motivation. Animal studies suggest that oxytocin may reduce food intake. The effects of oxytocin administration on eating behavior in humans, which could have important implications in eating-related disorders ranging from obesity to anorexia nervosa, have not been investigated. This double-blind placebo-controlled cross-over study of single-dose oxytocin administration investigates whether: 1. Caloric intake will decrease following administration of oxytocin versus placebo 2. Appetite will decrease following administration of oxytocin versus placebo 3. Resting energy expenditure will increase following administration of oxytocin versus placebo

Conditions

• Eating Behavior

Interventions

Type	Name	Description
DRUG	Oxytocin	Intranasal oxytocin 24 IU single-dose administration
DRUG	Placebo	Intranasal Placebo single-dose administration

Timeline

• Start date: 2012-01-01
• Primary completion: 2014-01-01
• Completion: 2014-01-01
• First posted: 2012-01-20
• Last updated: 2019-04-08

Locations

1 site across 1 country: United States