NCT01512511

Comparing Nitrous Oxide and Carbon Dioxide for Laparoscopic Cholecystectomy

Prospective Randomized Trial Comparing Nitrous Oxide and Carbon Dioxide for Laparoscopic Cholecystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Ahvaz Jundishapur University of Medical Sciences · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

There is no general agreement about the ideal gas for pneumoperitoneum. CO2, now in common use, has not compared to N2O sufficiently to disclose which one has minimal "physiological" invasiveness characters. Assigned randomly to carbon dioxide or nitrous oxide group, the hemodynamic and respiratory parameters (heart rate, mean arterial blood pressure, end-tidal CO2, minute ventilation, and O2 saturation) before pneumoperitoneum and during it were recorded. Pain, as perceived by patients, is measured 2, 4 and 24 hours after the procedure by visual analogue scale. Vomiting and use of analgesics and antiemetics were recorded and compared.

Conditions

• Pneumoperitoneum

Interventions

Type	Name	Description
PROCEDURE	nitrous oxide use for pneumoperitoneum creation	use nitrous oxide for create pneumoperitoneum in laparoscopic cholecystectomy

Timeline

• Start date: 2010-11-01
• Primary completion: 2011-03-01
• Completion: 2011-04-01
• First posted: 2012-01-19
• Last updated: 2012-01-19

Locations

1 site across 1 country: Iran