NCT01511575

Studying Biomarker Expression in Samples From Patients With Down Syndrome and Acute Myeloid Leukemia or Other Transient Myeloproliferative Disorder

Analysis of MicroRNA Expression in Down Syndrome Acute Myeloid Leukemia and the Transient Myeloproliferative Disorder

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: 3 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn about changes that occur in RNA and identify biomarkers related to cancer. PURPOSE: This research trial studies RNA samples from patients with Down syndrome and acute myeloid leukemia or other transient myeloproliferative disorder.

Detailed description

OBJECTIVES: * To compare miRNA expression in distinctive diagnostic groups: transient myeloproliferative disorder (TMD), Down syndrome (DS) acute megakaryocytic leukemia (AMkL), non-DS AMkL, and in remission DS samples (representing germline, non-malignant samples). OUTLINE: Archived RNA samples are analyzed for mature micro (mi)RNA expression by real-time RT-PCR. Results are then compared with miRNA expression of non-Down syndrome patients with acute megakaryocytic leukemia.

Conditions

• Leukemia

Interventions

Type	Name	Description
GENETIC	RNA analysis
GENETIC	reverse transcriptase-polymerase chain reaction
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2012-02-01
• Primary completion: 2016-05-01
• Completion: 2016-05-01
• First posted: 2012-01-18
• Last updated: 2016-05-17