NCT01507441

Studying DNA in Samples From Younger Patients With Down Syndrome and Acute Myeloid Leukemia Treated on COG-AAML0431 Clinical Trial

Whole Exon Sequencing of Down Syndrome Acute Myeloid Leukemia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 10 (estimated)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: 3 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies DNA samples from patients with Down syndrome and acute myeloid leukemia treated on COG-AAML0431 clinical trial.

Detailed description

OBJECTIVES: * To identify new genetic abnormalities associated with acute myeloid leukemia (AML) in patients with Down syndrome through whole-genome sequencing. OUTLINE: This is a multicenter study. Extracted DNA and RNA from cryopreserved specimens are analyzed for genomic sequencing, gene mutation, and microarray analysis.

Conditions

• Leukemia

Interventions

Type	Name	Description
GENETIC	gene mapping
GENETIC	microarray analysis
GENETIC	mutation analysis
GENETIC	nucleic acid sequencing
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2012-02-01
• Primary completion: 2016-05-01
• First posted: 2012-01-10
• Last updated: 2016-05-18