NCT01507363

Analgesic Effect of Gabapentin in Total Knee Arthroplasty (TKA)

Analgesic Effect of Perioperative Gabapentin in Total Knee Arthroplasty: A Randomized, Double-blind, Placebo-controlled, Dose-response Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 50 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Pain is a major problem after TKA. Gabapentin may reduce acute postoperative pain. The investigators therefore investigate the effect of Gabapentin as a perioperative analgesic.

Detailed description

Pain is a major problem after TKA. Studies indicate that Gabapentin may reduce acute postoperative pain. However, the optimal dose is unknown and there is constant controversy on analgesic versus side-effects. The investigators therefore investigate the effect of Gabapentin as a perioperative analgesic in a dose-related manner and with a sample-size allowing evaluation of side-effects.

Conditions

• Postoperative Pain
• Postoperative Sedation

Interventions

Type	Name	Description
DRUG	Gabapentin	Tables with Gabapentin (1300 mg/ day) for 7 days, starting on the day of surgery
DRUG	Gabapentin	Tables with Gabapentin (900 mg/day) for 7 days, starting on the day of surgery
DRUG	Placebo	Placebo tablets for 7 days, starting on the day of surgery

Timeline

• Start date: 2012-01-01
• Primary completion: 2013-11-01
• Completion: 2013-11-01
• First posted: 2012-01-10
• Last updated: 2014-04-11

Locations

3 sites across 1 country: Denmark