NCT01505699

Biomarkers in Samples From Patients With B-Cell Acute Lymphoblastic Leukemia

Micro RNA Expression Analysis in B-Lineage Adult Acute Lymphoblastic Leukemia From ALL Trial, E2993, Including Patients With Various Cytogenetic and Molecular Abnormalities

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 186 (actual)
• Sponsor: Eastern Cooperative Oncology Group · Network
• Sex: All
• Age: 15 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in samples from patients with acute lymphoblastic leukemia enrolled on ECOG-2993 clinical trial.

Detailed description

OBJECTIVES: * To identify microRNAs that behave as oncogenes or as tumor suppressor genes in B-lineage acute lymphoblastic leukemia (ALL) in vitro and in vivo. * To examine if single microRNA or signatures of microRNA correspond to different clinical outcomes in cytogenetically distinct B-ALL groups. OUTLINE: RNA from archived samples are analyzed for microRNA expression profile in vitro and in vivo.

Conditions

• Leukemia

Interventions

Type	Name	Description
GENETIC	RNA analysis
GENETIC	cytogenetic analysis
GENETIC	microarray analysis
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2012-01-06
• Primary completion: 2012-02-06
• Completion: 2012-02-06
• First posted: 2012-01-06
• Last updated: 2017-05-17