Trials / Unknown
UnknownNCT01503645
Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism
Epidemiology of Chinese Herb Nephropathy and Its Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (estimated)
- Sponsor
- National Taiwan University Hospital · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Accepted
Summary
1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA). 2. AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer 3. Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN. 4. By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.
Conditions
Timeline
- Start date
- 2006-05-01
- First posted
- 2012-01-04
- Last updated
- 2012-11-14
Locations
2 sites across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT01503645. Inclusion in this directory is not an endorsement.