NCT01501968

Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicity

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 54 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Ascorbic acid (Vitamin C) could protect renal toxicity from colistin.

Detailed description

Renal toxicity due to colistin therapy is common. Ascorbic acid (vitamin C) has been shown to prevent colistin associated renal toxicity in animals. This study is conducted to determine if acorbic acid can prevent Colistin-Associated Nephrotoxicity.

Conditions

• Drug Safety

Interventions

Type	Name	Description
DRUG	Colistin	Colistimethate sodium 2.5-5mg/kg iv per day
DRUG	Colistin + Ascorbic acid	Colistimethate sodium 2.5-5mg/kg iv per day and ascorbic acid 2 grams iv q 12 hours

Timeline

• Start date: 2012-01-01
• Primary completion: 2013-12-01
• Completion: 2013-12-01
• First posted: 2011-12-30
• Last updated: 2011-12-30

Locations

1 site across 1 country: Thailand