Trials / Completed
CompletedNCT01500499
Role of Biomarkers in Disease Progression in Samples From Patients With Acute Myeloid Leukemia
The Role of AF1q in Progression of Leukemia
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (estimated)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 30 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies the role of biomarkers in disease progression in samples from patients with acute myeloid leukemia.
Detailed description
OBJECTIVES: * To determine the subcellular localization of the MLL-AF1q fusion protein in leukemia cells. OUTLINE: Cryopreserved specimens are analyzed for MLL-AF1q fusion protein and AF1 gene expression by mass spectrometry, western blot analysis, semi-quantitative PCR, and qPCR.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | gene expression analysis | |
| GENETIC | gene rearrangement analysis | |
| GENETIC | polymerase chain reaction | |
| GENETIC | protein analysis | |
| GENETIC | western blotting | |
| OTHER | laboratory biomarker analysis | |
| OTHER | mass spectrometry |
Timeline
- Start date
- 2011-12-01
- Primary completion
- 2016-05-01
- First posted
- 2011-12-28
- Last updated
- 2016-05-18
Source: ClinicalTrials.gov record NCT01500499. Inclusion in this directory is not an endorsement.