NCT01499810

Efficacy and Safety of Radiofrequency Renal Denervation in Drug Resistant Hypertension

Study of Efficacy and Safety of Radiofrequency Sympathetic Renal Denervation for Treatment of Drug Resistant Hypertension

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Single-center, single group study of the efficacy and safety of transcatheter renal denervation for treatment of patients with essential hypertension uncontrolled despite combined pharmacotherapy including 3 or more hypotensive drugs one of which is a diuretic. Bilateral transcatheter renal denervation will be performed on the top of existed pharmacotherapy. Change in blood pressure (BP), left ventricle (LV) mass, carotid artery thickness, renal artery blood flow and renal function, will be assessed at 6 and 12 months of follow-up.

Conditions

• Hypertension

Interventions

Type	Name	Description
PROCEDURE	Bilateral radiofrequency sympathetic renal denervation	Bilateral radiofrequency sympathetic renal denervation is performed as percutaneous transluminal radiofrequency (RF) ablation of neural pathways in the renal artery walls and surrounding tissue using standard equipment for RF ablation of cardiac electrical pathways

Timeline

• Start date: 2010-03-01
• Primary completion: 2013-12-01
• Completion: 2014-01-01
• First posted: 2011-12-26
• Last updated: 2021-10-28
• Results posted: 2014-09-17

Locations

1 site across 1 country: Russia