NCT01496794

Endophthalmitis Cultures

Prospective Surveillance of Patients With Endophthalmitis for Multi-antibiotic Resistance (PROSPER) Study

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 3 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The intent of this surveillance study will be to obtain written permission from patients with bacterial endophthalmitis in order to compare sterilization rates of their cultured bacterial isolates to standard therapy (vancomycin and ceftazidime) versus combination therapy with vancomycin, ceftazidime, and moxifloxacin. Research hypothesis: 1. Cultured bacterial isolates will demonstrate faster in vitro sterilization rates with combination treatment (vancomycin, ceftazidime, and moxifloxacin) compared to "standard therapy" with vancomycin and ceftazidime. 2. Longitudinal analysis of resistance patterns of cultured isolates will show increasing rates of multi-antibiotic resistance.

Detailed description

Adult patients over 18 years of age presenting with endophthalmitis and able to sign consent.

Conditions

• Endophthalmitis

Timeline

• Start date: 2011-10-01
• Primary completion: 2016-04-01
• Completion: 2016-04-01
• First posted: 2011-12-21
• Last updated: 2017-02-23

Locations

1 site across 1 country: United States