NCT01492998

Role of FXR in Hepatitis C Virus Replication

Study of the Role of the Biliary Salts Nuclear Receptor FXR in Hepatitis C Virus Replication

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: Male
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

In vitro in the hepatitis C virus (HCV) replicon system, modulation of the biliary salts nuclear receptor FXR by either agonists or antagonists respectively increases or decreases the replication of HCV (J Hepatol, 2008, 48: 192-9). One antagonist of FXR is a vegetal sterol, guggulsterone, that is extracted from the Commiphora mukul tree and that has already been given safely to hyper cholesterolemic patients in a clinical trial (JAMA 2003, 290: 765-72). The aim of this trial is to test the effect of the FXR antagonist guggulsterone given orally, three times a day, on the viral load in 15 HCV genotype 1 chronically infected patients.

Conditions

• Chronic Hepatitis C

Interventions

Type	Name	Description
OTHER	guggulsterone, a natural FXR antagonist.	Gugulipid®, natural extract from Commiphora mukul tree, containing 2.5% guggulsterone

Timeline

• Start date: 2010-01-01
• Primary completion: 2010-03-01
• First posted: 2011-12-15
• Last updated: 2011-12-15

Locations

1 site across 1 country: France