NCT01492322

SPECT Imaging of DAT Genotype

Use of SPECT (Single-photon Emission Computed Tomography) to Examine the Role of DAT (Dopamine Transporter) Genotype in Motivated Smoking Behavior

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 14 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

A polymorphism in the dopamine transporter (DAT) may determine how much dopamine is available at the synapse and this may affect the underlying reasons for relapse in smokers. This research will use Single-photon emission computed tomography SPECT and the DAT-specific ligand, TRODAT (Dopamine Transporter Density by \[99mTc\]), to examine the availability of DAT in smokers grouped by genotype in the sated (just having smoked) and withdrawal (4 hours without smoking) conditions.

Detailed description

There will be 2 SPECT scans for each smoker who participates in this research. One SPECT scan when the smoker is sated with nicotine and one where the smoker is in withdrawal

Conditions

• Nicotine Withdrawal

Interventions

Type	Name	Description
RADIATION	TRODAT	Smoker will receive a TRODAT injection

Timeline

• Start date: 2011-11-01
• Primary completion: 2013-07-01
• Completion: 2014-10-01
• First posted: 2011-12-14
• Last updated: 2015-10-12

Locations

1 site across 1 country: United States