NCT01492283

Pathophysiological Implications of the Incretin Hormones in Patients With Liver Disease With and Without Diabetes

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 48 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The main objective of this study is to analyze the pathophysiological implications of glucagon and the incretin hormones in patients with liver disease (Non alcoholic fatty liver disease (NAFLD) or cirrhosis) with and without diabetes compared with healthy controls. The present study will contribute significantly to the understanding of the pathophysiology of liver disease and glucose metabolism. The final goal is that the results could pave the way for new treatment modalities for patients with liver disease.

Detailed description

Comparison of of insulin secretion (Area Under the Curve (AUC)) during the experimental days. Furthermore a comparison of GIP, GLP1 and glucagon responses as well as plasma glucose levels.

Conditions

• Non Alcoholic Fatty Liver Disease
• Type 2 Diabetes
• Liver Cirrhosis

Interventions

Type	Name	Description
OTHER	OGTT	50g waterfree glucose dissolved in 300 ml water consumed over 5 min.
OTHER	IIGI	iso glycemic intravenous (iv) glucose infusion (IIGI) with 20% glucose

Timeline

• Start date: 2011-12-01
• Primary completion: 2013-05-01
• Completion: 2014-07-01
• First posted: 2011-12-14
• Last updated: 2014-07-10

Locations

1 site across 1 country: Denmark