NCT01491243

N-GAL Allows Intensive Treatment of Contrast Induced Nephropathy

Neutrophil gElatinase-associated Lipocalin alloWs Intensive treatMent Of cOntrast Induced Nephropathy in Patients With Urgent/Emergency Percutaneous Coronary Intervention

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Roma La Sapienza · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Patients who undergo urgent/emergency coronary angiography can not receive any preventive treatment of contrast induced nephropathy. We tested the hypothesis that Neutrophil gelatinase-associated lipocalin (NGAL), a new biomarker predictive for AKI, allows early and effective treatment of contrast induced nephropathy in patients with urgent/emergency coronary angiography

Detailed description

Background Patients who undergo urgent/emergency coronary angiography can not receive any preventive treatment of contrast induced nephropathy. An acute kidney injury is generally detected too late to allow effective intervention in patients who undergo urgent/emergency coronary angiography. Neutrophil gelatinase-associated lipocalin (NGAL) is a new biomarker predictive for AKI already shown to be useful for earlier diagnosis of contrast induced nephropathy. Purpose The primary objective of this study is to to test the hypothesis that a NGAL-driven early intensive strategy can reduce the occurrence of contrast induced nephropathy in patients with urgent/emergency coronary angiography

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DRUG	Intensive treatment with sodium bicarbonate	i.v., sodium bicarbonate (3 ml/kg/h for 1 hour, then 1 ml/kg/h for 7 h) followed by i.v. saline for 48 h in case of abnormal NGAL findings
DRUG	Standard treatment with saline infusion	i.v. 1 ml/kg/h saline infusion for 48 h in case of abnormal NGAL findings

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-12-01
• Completion: 2017-12-01
• First posted: 2011-12-13
• Last updated: 2013-03-07

Locations

1 site across 1 country: Italy