NCT01489137

The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation

The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation in the Patients Undergoing Neurosurgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to estimate the EC90 of remifentanil blunting hemodynamic changes to head fixation in the patients undergoing neurosurgery.

Conditions

• Brain Tumor
• AVM
• ICH

Interventions

Type	Name	Description
DRUG	remifentanil	According to previous patient's response, the investigators will allocate the effect site concentration of remifentanil of next patient during head fixation. And, For this allocation of dose of remifentanil the investigators use biased coin design up-and-down method. For the first patient, the dose of remifentanil would be fixed at 5.5ng/ml which we predict as EC90. And, step size of dose is 0.5ng/ml.

Timeline

• Start date: 2011-11-01
• Primary completion: 2012-02-01
• First posted: 2011-12-09
• Last updated: 2012-08-17

Locations

1 site across 1 country: South Korea