NCT01483755

Delayed Postconditioning

Delayed Angioplasty Postconditioning in STEMI Patients

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators previously reported that angioplasty postconditioning reduces infarct size (cardiac enzyme release) in STEMI patients with a fully occluded coronary artery at hospital admission. Animal studies have suggested that the time window for applying brief episodes of ischemia and reperfusion aimed at triggering postconditioning's protection is very narrow, i.e. does not expand beyond 1 minute after reflow. We sought to address whether this window might be larger in humans, i.e. whether STEMI patients might be protected several minutes after undergoing spontaneous reperfusion before admission coronary angiography. Therefore, STEMI patients (onset of chest pain less than 12 hours) with a TIMI flow grade \> 1 were eligible for that study. Angioplasty postconditioning was completed as already published and infarct size was assessed by measuring cardiac enzymes release.

Conditions

• Myocardial Reperfusion Injury

Interventions

Type	Name	Description
PROCEDURE	Postconditioning	Postconditioning consists of four cycles of one minute balloon inflation followed by one minute of balloon deflation, with the initial inflation being started within the first minute after reopening of the culprit coronary artery.
PROCEDURE	Percutaneaous intervention	Conventional primary percutaneaous intervention

Timeline

• Start date: 2009-07-01
• Primary completion: 2012-06-01
• Completion: 2012-06-01
• First posted: 2011-12-01
• Last updated: 2025-12-19

Locations

5 sites across 1 country: France