NCT01482416

Vascular Effect of Estrogens Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery

Flow-mediated Evaluation of the Brachial Artery of Climacteric Women Using Estradiol and Placebo. Randomized, Double Blinded, Placebo Controlled Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Federal University of Minas Gerais · Academic / Other
• Sex: Female
• Age: 45 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to evaluate the vascular effects of estrogens on climacteric women measured by flow-mediated evaluation of the brachial artery using high resolution ultrasound and compare to placebo.

Detailed description

The interruption of the secretion of sex steroids that occurs after menopause, determines a change in vascular pattern at various levels. As a result, several side effects might appear and interfere with women's quality of life and health. The use of hormone replacement therapy has contributed to the improvement in these effects. It has been observed vascular beneficial effects of sex steroids in premenopausal women, and of hormone replacement therapy (HRT) in climacteric women, on the central retinal arteries. The objective of this study is to evaluate the effects of conjugated equine estrogen on flow-mediated dilation of the brachial artery.

Conditions

• Unspecified Injury of Brachial Artery, Left Side, Initial Encounter

Interventions

Type	Name	Description
DRUG	Estrogens, Conjugated (USP)	Experimental group will use 0.625mg/day during 30 days
DRUG	Placebo	Placebo group will use placebo once/day during 30 days

Timeline

• Start date: 2011-11-01
• Primary completion: 2014-08-01
• Completion: 2014-08-01
• First posted: 2011-11-30
• Last updated: 2014-08-15

Locations

1 site across 1 country: Brazil