NCT01477450

Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of Cincinnati · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study will compare the ability of pulsed-dose oxygen from a concentrator to reverse altitude-induced hypoxemia compared to compressed gas from a standard oxygen cylinder.

Detailed description

Subjects will be monitored non-invasively with pulse oximetry, end-tidal carbon dioxide, tissue oxygenation and ECG. The mean seal level oxygen saturation will be recorded.Subjects exposed to an altitude of 14,000 feet will experience moderate hypobaric hypoxia. The mean oxygen saturation at this altitude is 83%. Subjects will receive oxygen from both an oxygen concentrator or a cylinder of oxygen following exposure to hypobarism. Oxygen from each source will be increased in 1 liter per minute increments until the oxygen saturation returns to the baseline sea level oxygen saturation. The oxygen requirement to return oxygen saturation to baseline values will be recorded. The flow from the concentrator and the cylinder will be compared.

Conditions

• Hypoxemia
• Hypobaric Hypoxemia

Interventions

Type	Name	Description
DEVICE	Pulse-dose oxygen	Pulsed-dose oxygen delivery from an oxygen concentrator
DEVICE	Cylinder oxygen delivery	Oxygen delivery from an oxygen cylinder

Timeline

• Start date: 2011-10-01
• Primary completion: 2012-03-01
• Completion: 2012-09-01
• First posted: 2011-11-22
• Last updated: 2014-09-26
• Results posted: 2014-09-26

Locations

1 site across 1 country: United States