NCT01472692

Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure

Treatment of Uric Acid With the Xanthine Oxidase Inhibitor Febuxostat: Effects on Blood Pressure, Metabolic Markers, and Aortic Stiffness in Prehypertensive

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 47 (actual)
• Sponsor: University of California, San Diego · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

High normal blood pressure, also called prehypertension, is a significant problem. High uric acid in the blood, the same thing that causes gout, may cause higher blood pressures. The investigators plan to monitor the effects of the drug febuxostat(trade name Uloric) on blood pressure and stiffness of the main blood vessels and see if lowering uric acid has any effect.

Conditions

• Prehypertension
• Gout
• Pulse Wave Velocity
• Hypertension
• 24 Hour Blood Pressure

Interventions

Type	Name	Description
DRUG	Febuxostat	80mg PO daily for 8 weeks

Timeline

• Start date: 2011-10-01
• Primary completion: 2014-03-01
• Completion: 2014-03-01
• First posted: 2011-11-16
• Last updated: 2019-12-16
• Results posted: 2019-12-16

Locations

1 site across 1 country: United States