NCT01468480

Human Pulpal Response After Pulp Capping With Four Different Agents

Comparison of Human Pulpal Response After Pulpal Exposure to Common Treatments and Single-visit MTA

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Islamic Azad University, Sanandaj · Academic / Other
• Sex: All
• Age: 10 Years – 16 Years
• Healthy volunteers: Accepted

Summary

Application of four different pulp capping methods on human sound premolars after intentional exposure of the buccal pulp horn through a class one occlusal cavity.

Detailed description

The purpose of this clinical trial is to compare the effect of different direct pulp capping methods on human pulpal response in the terms of inflammation \& dentinal bridge formation. Methods: Eight patients providing 32 sound first premolars are selected. As recommended by ISO / TC 7405 pulpal exposure will be performed through a class I cavity. Four groups of eight specimens each will be defined according to the pulp capping method. Group A, will receive chemical set calcium hydroxide (Dycal). Group B, will receive mineral Trioxide Aggregate (MTA) according to manufacturer's instruction. Group C, will receive MTA and after its primary setting, within 15 minutes, the cavity is restored in the same appointment. Group D, will receive Multical as a direct pulp capping agent. Specimens will be assessed in the terms of dentinal bridge formation, its appearance compared to natural dentin, its thickness and inflammatory pulpal response. The last item will be scored 0-3 in which 0 corresponds to none, 1 to minimal, 2 to moderate and 3 to severe inflammation. In case of an abscess or true tissue necrosis, a score of 4 will be given as recommended by ISO / TC 7405.

Conditions

• Dental Pulp Exposure

Interventions

Type	Name	Description
DRUG	Pro Root MTA	application of MTA in second group and 24 hour interval before restoration
DRUG	Pro Root MTA- single visit	application of MTA in third group and 15 minute interval before restoration
DRUG	MultiCal	application of Multical in forth group as a pulp dressing agent
DRUG	Dycal	application of Dycal in first group as a pulp dressing agent

Timeline

• Start date: 2010-06-01
• Primary completion: 2011-02-01
• Completion: 2011-03-01
• First posted: 2011-11-09
• Last updated: 2011-11-09

Locations

1 site across 1 country: Iran