NCT01468116

The Effect of Roux-en-Y Gastric Bypass on Mitochondrial Function in Type 2 Diabetes

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Roux-en-Y gastric bypass (RYGB) surgery induces resolution of type 2 diabetes, often within days after surgery and before significant weight loss. The aim of this study is to investigate whether changes in mitochondrial function contributes to the early improvement of type 2 diabetes after RYGB.

Detailed description

Mitochondrial dysfunction has been linked to development of insulin resistance in the muscle and hence to the pathogenesis of type 2 diabetes. Mitochondrial function can be studied non-invasively by 31 Phosphor Magnetic Resonance spectroscopy (31PMRS). In this study we will investigate changes in mitochondrial function using the combination of 31 PMRS and Near Infra-Red Spectroscopy (NIRS) after gastric bypass.

Conditions

• Type 2 Diabetes
• Obesity

Timeline

• Start date: 2011-03-01
• Primary completion: 2013-06-01
• Completion: 2013-12-01
• First posted: 2011-11-09
• Last updated: 2011-11-09

Locations

1 site across 1 country: Denmark