NCT01460563

Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia

Effects of Valproic Acid and Magnesium Sulphate on Rocuronium Requirement and Postoperative Analgesia in Patients Undergoing Craniotomy for Cerebrovascular Surgery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesized that valproic acid will increase rocuronium requirement and MgSO4 infusion would reduce requirement of muscle relaxant in craniotomy patients preloaded with sodium valproate.

Detailed description

Magnesium sulfate (MgSO4) is known to reduce requirement of muscle relaxant.

Conditions

• Cerebral Aneurysm

Interventions

Type	Name	Description
DRUG	Magnesium Sulfate	MgSO4 infusion: 50mg/kg bolus followed by continuous infusion
DRUG	0.9% saline	0.9% saline as same dose as MgSO4 as placebo
DRUG	0.9% saline	0.9% saline as same dose as MgSO4 as placebo

Timeline

• Start date: 2011-10-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2011-10-27
• Last updated: 2011-12-29

Locations

1 site across 1 country: South Korea