NCT01449864

Proton Radiotherapy for Upper Gastrointestinal Malignancies

A Feasibility and Registration Study of Proton Radiotherapy for Upper Gastrointestinal Malignancies

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Abramson Cancer Center at Penn Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objectives are to determine feasibility and the acute toxicity profile of proton therapy with concurrent continuous infusion 5-FU chemotherapy. Secondary objectives are to determine late toxicities and to generate preliminary data on clinical efficacy.

Detailed description

This protocol invites patients with cancer of the upper digestive tract who will receive simultaneous proton radiation therapy and chemotherapy. The purpose of this study is to use a newer form of radiation therapy called proton radiation and to determine if its use is safe and effective in people with this type of cancer. Doctors will assess the safety of this method of treatment, record the side effects participants experience while receiving the standard dose of proton radiation.

Conditions

• Gastrointestinal Cancer

Interventions

Type	Name	Description
RADIATION	Proton therapy	The goal of radiation therapy is to deposit the majority of the radiation dose to the target while minimizing the dose to the surrounding normal tissues.

Timeline

• Start date: 2011-08-01
• Primary completion: 2015-12-01
• Completion: 2019-12-01
• First posted: 2011-10-10
• Last updated: 2020-04-15
• Results posted: 2019-11-04

Locations

1 site across 1 country: United States