NCT01448863

Metabolomic Embryo Profiles of Obese in Vitro Fertilization (IVF) Patients and Their Relationship With Polycystic Ovary Syndrome (PCO)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 28 (actual)
• Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA · Academic / Other
• Sex: All
• Age: 18 Years – 38 Years
• Healthy volunteers: Accepted

Summary

The present study aims to elucidate if there is a metabolomic profile alteration in the embryos of obese women in order to understand if the reduced implantation rate observed in these patients is directly related to this factor. Furthermore, the investigators seek to establish if there is any difference between obese women with Polycystic Ovary Syndrome (PCO) and without PCO. The investigators compare these metabolomic profile embryos with embryos of egg-donation programme.

Conditions

• Infertility
• Obesity

Interventions

Type	Name	Description
OTHER	Culture medium metabolomic analysis	During the embryo transfer at day 3, the investigators keep and freeze a small drop of the culture medium of each embryo transferred. Each drop of culture medium will have a volume of 40-50 microliters, before freezing is spun at 10.000 rps to avoid any possible contamination. The frozen media culture is analyzed for the metabolomic profile.

Timeline

• Start date: 2011-10-01
• Primary completion: 2014-10-01
• Completion: 2014-10-01
• First posted: 2011-10-07
• Last updated: 2015-03-10

Locations

2 sites across 1 country: Spain