NCT01446523

S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE

Serum Endotoxins, Inflammatory Mediators and MR Spectroscopy Before and After Treatment in Minimal Hepatic Encephalopathy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Govind Ballabh Pant Hospital · Other Government
• Sex: All
• Age: 15 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine S.endotoxins , inflammatory mediators and Magnetic Resonance Spectroscopy (MRS) before and after treatment in patients of cirrhosis and minimal hepatic encephalopathy.

Detailed description

60 patients of cirrhosis with Minimal Hepatic Encephalopathy (MHE) who fulfills the inclusion \& exclusion criteria will be the part of study. Study patients will be divided in to two groups ( n=30 in each group). Group L patients will receive lactulose therapy while Group NL will receive placebo. After 3 months , S.endotoxins , inflammatory mediators and MRS will be repeated in each group.

Conditions

• Hepatic Encephalopathy

Interventions

Type	Name	Description
DRUG	placebo	Syrup, 30 ml BD for 3 months in Gr. NL
DRUG	Lactulose	Syrup 30 ml BD for 12 weeks

Timeline

• Start date: 2011-10-01
• Primary completion: 2012-02-01
• Completion: 2012-02-01
• First posted: 2011-10-05
• Last updated: 2012-04-10

Locations

1 site across 1 country: India