NCT01444872

Study to Evaluate TRV120027 on Renal Pharmacodynamics in Patients With Heart Failure and Renal Dysfunction

A Randomized, Single-Blind, Placebo-Controlled, Adaptive, Ascending Dose Study to Evaluate the Effects of TRV120027 on Renal Pharmacodynamics in Patients With Heart Failure and Mild to Moderate Renal Dysfunction

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Trevena Inc. · Industry
• Sex: All
• Age: 18 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of TRV120027 in subjects with heart failure and mild to moderate renal dysfunction.

Conditions

• Heart Failure
• Kidney Disease

Interventions

Type	Name	Description
DRUG	TRV120027	IV infusion
DRUG	Normal Saline	IV infusion

Timeline

• Start date: 2011-08-01
• Primary completion: 2012-05-01
• Completion: 2012-06-01
• First posted: 2011-10-03
• Last updated: 2012-08-27

Locations

4 sites across 1 country: United States