NCT01444664

Aneurysm Wall Histology Registry

Aneurysm Wall Histology and Correlation With Cerebrospinal Fluid and Blood Plasma Registry

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this prospective registry is to determine if patients harboring intracranial aneurysms have any predictive markers between aneurysm wall tissue, cerebrospinal fluid and blood plasma.

Detailed description

To design a registry to evaluate the wall of intracranial aneurysms during open surgical clipping by direct photographic appearance, wall biopsy samples, CSF and blood plasma fluid collection (Interleukins; IL-8/ Matrix Metalloproteinase; MMP-9) for complete evaluation and comparison. The focus of the registry will be to determine the presence of aneurysmal wall defects, mural clot, atherosclerotic and atheroma, wall permeability and delamination. These findings will then be correlated to the collected CSF and blood values to determine if there is any direct features of the aneurysm wall that would predict any of the reported post embolic syndromes. The collected data can also be correlated to the peroperative imaging, (MRI, CT and Angiogram).

Conditions

• Brain Aneurysm

Interventions

Type	Name	Description
PROCEDURE	Surgical Clipping of Aneurysm	Surgical clipping of intracranial aneurysm

Timeline

• Start date: 2010-06-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2011-10-03
• Last updated: 2016-03-24

Locations

10 sites across 2 countries: United States, Canada