NCT01443559

Xenogenic Keratoplasty From Porcine Cornea

Phase I Study of Xenogenic Keratoplasty From Porcine Cornea in the Treatment of Infectious Corneal Ulcer

• Status: Suspended
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Xiamen University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Acellular porcine cornea is a valid substitution for human cornea because of its similar biological structure, corneal superficial curvature and good histocompatibility toward human. Facing the lack of human cornea donor, it is hypothesised that using acellular lamellar porcine cornea as an alternative of lamellar human cornea to treat infectious corneal ulcer.

Detailed description

Acellular porcine cornea eligibility criteria: 1. fresh porcine cornea, 2. porcine cornea keeping transparent without scar, neovascularization or corneal ulcer, 3. porcine cornea keeping integrative corneal epithelium and endothelium, 4. acellular porcine cornea keeping transparent.

Conditions

• Porcine Corneal Xenograph

Interventions

Type	Name	Description
GENETIC	Xenogenic cornea	lamellar acellular xenogenic corneas were sterilised by radiation
GENETIC	homogenic cornea	homogenic corneas were sterilised by radiation

Timeline

• Start date: 2011-09-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2011-09-29
• Last updated: 2015-07-17

Locations

1 site across 1 country: China