NCT01441921

Effect of Pistachio Intake on Insulin Resistance and Type 2 Diabetes Mellitus

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Institut Investigacio Sanitaria Pere Virgili · Academic / Other
• Sex: All
• Age: 25 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Hypothesis: Chronic intake of pistachios improves glucose metabolism and insulin resistance status thus contributing to decrease the risk of type 2 diabetes mellitus and its associated abnormalities.

Detailed description

In free-living overweight or obese adult with impaired fasting glucose or impaired glucose tolerance we will compare the effects of a pistachio-rich diet or a Mediterranean Diet on: * Fasting glucose levels, hemoglobin A1c, insulin, C peptide, HOMA IR, advanced glycation end products and soluble receptor of advanced glycation-end products. * Peripheral haemostatic parameters. * Plasma inflammatory markers. * Lymphocyte expression of toll-like receptors, C peptide, resistin and interleukin-6 in peripheral leukocytes. * Lymphocyte glucose transport and expression of glucose transporter 4 in peripheral blood leukocytes. * Platelet function including platelet number, mean platelet volume, platelet factor 4 levels and urinary 11-dehydro-thromboxane B2.

Conditions

• Type 2 Diabetes Mellitus

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Pistachios	Participants are randomised crossover clinical trial of 4-months trials separated by a 2-week washout period. Total duration of intervention and follow-up is nine months.
OTHER	control diet	Participants are randomised crossover clinical trial of 4-months trials separated by a 2-week washout period. Total duration of intervention and follow-up is nine months.

Timeline

• Start date: 2011-09-01
• Primary completion: 2016-09-01
• Completion: 2017-09-01
• First posted: 2011-09-28
• Last updated: 2019-02-11

Locations

1 site across 1 country: Spain