NCT01440972

Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: University of Iowa · Academic / Other
• Sex: Female
• Age: 45 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to asses the efficacy of a 4 week low-intensity resistance training program with concurrent application of partial blood flow restriction (PBFR) to the exercising limbs to improve quadriceps strength and size, leg muscle power, and mobility in women at risk for developing symptomatic knee osteoarthritis. The primary outcome will be change in isotonic double leg-press 1 repetition maximum (1RM) strength. The investigators will test the following hypotheses. In comparison with low-intensity resistance training without use of PBFR, a four-week low-intensity resistance-training program with PBFR will: Primary Hypothesis: Increase (a) double leg-press 1RM strength and (b) isokinetic knee extensor strength Secondary Hypotheses: 1. Increase quadriceps muscle volume assessed by MRI 2. Increase lower limb muscle power on (a) double leg-press at 40% 1RM and (b) a timed stair climb 3. Not adversely effect knee pain or quality of life assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire

Conditions

• Knee Osteoarthritis
• Symptomatic Knee Osteoarthritis

Interventions

Type	Name	Description
OTHER	partial blood flow restriction (PBFR)	low intensity resistance training with partial blood flow restriction 3 times/week for 4 weeks.
OTHER	low intensity resistance training	low intensity resistance training without partial blood flow restriction

Timeline

• Start date: 2011-09-01
• Primary completion: 2011-11-01
• Completion: 2011-11-01
• First posted: 2011-09-27
• Last updated: 2016-12-05
• Results posted: 2015-07-30

Locations

1 site across 1 country: United States