NCT01438515

Randomized Controlled Trial of Standard Versus Systemic Decolonization Therapy for the Eradication of Methicillin-resistant Staphylococcus Aureus (MRSA) Colonization

Randomized Controlled Trial of Chlorhexidine Gluconate, Intranasal Mupirocin, Rifampin and Doxycycline Versus Chlorhexidine Gluconate and Intranasal Mupirocin Alone for the Eradication of Methicillin-resistant Staphylococcus Aureus Among an Ambulatory Patient Population

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Horizon Health Network · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

MRSA decolonization may reduce the risk of subsequent MRSA infection and further transmission. A recent randomized controlled trial demonstrated that systemic decolonization may be safe and effective among hospitalized patients when compared to no treatment. As a large number of the investigators patients require re-admission and further transmission may take place in the community, the investigators are comparing the standard decolonization protocol for MRSA eradication to the systemic decolonization protocol among an ambulatory population. Standard decolonization protocols, which use only topical agents, are limited in efficacy. The method of systemic decolonization to be studied here appears to have greater efficacy than the standard approach using only topical agents. However, concerns have been raised that the increased use of systemic antibiotics may lead to increased levels of drug resistance adverse effects, without sustained decolonization. This study seeks to provide further data to help answer these questions and provide guidance for further policy development and implementation.

Conditions

• Methicillin-resistant Staphylococcus Aureus

Interventions

Type	Name	Description
DRUG	Rifampin	600mg po once daily x 7 days
DRUG	Doxycycline	100mg po twice daily x 7 days
OTHER	2% mupirocin ointment	\~ 1cm applied to the anterior nares twice daily for 7 days
OTHER	4% chlorhexidine gluconate	Daily full body wash (including hair) for 7 days

Timeline

• Start date: 2008-08-01
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2011-09-22
• Last updated: 2020-02-17

Locations

1 site across 1 country: Canada