NCT01436851

Nasal Provocation Testing in Occupational Rhinitis

Nasal Provocation Testing With Nasal Lavage in Allergic and Non-allergic Occupational Rhinitis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Haukeland University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

In a previous study the investigators found that many bakery workers were sensitized to storage mites, and many had rhinitis symptoms. The role of storage mites as an occupational allergen with clinical relevance has been questioned, and the investigators wanted to investigate whether a nasal provocation with a storage mite extract would trigger symptoms and objective signs of rhinitis in bakery workers and a control group.

Detailed description

The investigations include allergy testing with skin prick testing, and measuring of specific Immunoglobulin E (IgE) in sera, answering a questionnaire, and symptom scoring before and after provocations. The participants will be investigated one day with a placebo, and another day with the allergen extract of either Acarus Siro or Lepidoglyphus Destructor. As a measurement of nasal patency we use the nasal peak inspiratory flow meter, but also clinical scoring of nasal secretion and blockage. Indices of inflammation (ECP and alfa-Macroglobulin) will be monitored in nasal lavage.

Conditions

• Allergic Rhinitis (Disorder)

Interventions

Type	Name	Description
BIOLOGICAL	Storage mite allergen extracts	Nasal provocation with increasing doses of storage mite allergen extracts

Timeline

• Start date: 2010-11-24
• Primary completion: 2011-09-01
• Completion: 2014-12-01
• First posted: 2011-09-20
• Last updated: 2017-08-16

Locations

1 site across 1 country: Norway