NCT01436604

Early Detection of Cardiac Toxicity of Trastuzumab (Herceptin ®) in Patients Treated for Breast Carcinoma: Value of Magnetic Resonance Imaging

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: Centre Francois Baclesse · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The main objective of this study is to compare the proportions of late enhancement in patients with Left ventricular (LV) dysfunction as Herceptin ® and in a control group consisting of patients who did not have LV dysfunction after 6 months under the same treatment.

Conditions

• Cancer, Breast
• LV Dysfunction

Interventions

Type	Name	Description
OTHER	Cardiac MRI	The examinations will be conducted on an MRI with a dedicated antenna heart, by a physician with expertise in cardiac MRI. After establishing a good quality ECG synchronization, the following sequences are carried out successively: * Sequences locating anatomical * T2 black blood (such as ESF) * rapid sequence of cine-MRI (such as balanced FFE) vertical and horizontal long axis and short axis of the base to the apex * T1-weighted sequence with inversion recovery for the assessment of possible consequences of cell damage.

Timeline

• Start date: 2012-02-01
• Primary completion: 2015-08-01
• Completion: 2017-05-01
• First posted: 2011-09-19
• Last updated: 2017-07-28

Locations

4 sites across 1 country: France