NCT01432522

A Study for Absorption of Intranasal Epinephrine Compared to Conventional Intramuscular Epinephrine

Comparison of Absorption of Epinephrine Into the Circulation After Epinephrine Intranasal Spray Administration and After Intramuscular Injection

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Siriraj Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study is a preliminary report of pharmacokinetic data of epinephrine administered via intranasal route (IN) comparing with intramuscular (IM) route in healthy adult volunteers.

Detailed description

Patients are reluctant to use Epipen® on emergency basis, perhaps because of improperly training, hesitancy and fear of needle. Other route of administration of epinephrine (EPI) may be more benefit such as intranasal route.

Conditions

• Anaphylaxis

Interventions

Type	Name	Description
DRUG	Epinephrine	1. Intranasal epinephrine 5 mg /spray 2. Intramuscular epinephrine 0.3 mg 3. Intranasal saline spray

Timeline

• Start date: 2010-07-01
• Primary completion: 2011-08-01
• Completion: 2011-09-01
• First posted: 2011-09-13
• Last updated: 2011-09-13

Locations

1 site across 1 country: Thailand