NCT01430637

Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1

Comprehensive Genome Sequencing of Desmoplastic Small Round Cell Tumors

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is studying genes in samples from younger patients with desmoplastic small round cell tumor registered on COG-D9902 or COG-ABTR01B1.

Detailed description

OBJECTIVES: * To perform whole-exome sequencing on desmoplastic small round cell tumor (DSRCT) samples and their available matched normal samples to identify novel mutations, single nucleotide polymorphisms, or copy number changes associated with these tumors. * To identify regions of interest that may be involved in the pathogenesis (including the region of EWSR1-WT1 translocation) from the whole-exome sequencing and perform detailed resequencing and transcriptone sequencing to further define the molecular aberrations at the RNA level. OUTLINE: This is a multicenter study. Archived tumor tissue samples are analyzed for DNA sequencing, effects of RNA on gene expression levels, novel RNA isoforms, splice variants, and translocations.

Conditions

• Sarcoma

Interventions

Type	Name	Description
GENETIC	DNA analysis
GENETIC	RNA analysis
GENETIC	gene expression analysis
GENETIC	mutation analysis
GENETIC	nucleic acid sequencing
GENETIC	polymerase chain reaction
OTHER	laboratory biomarker analysis
OTHER	pharmacogenomic studies

Timeline

• Start date: 2011-09-01
• Primary completion: 2016-05-01
• First posted: 2011-09-08
• Last updated: 2016-05-18