NCT01430520

Analgesic Effect of Escitalopram in Total Knee Arthroplasty (TKA)

Analgesic Effect of Perioperative Escitalopram for Patients With High Preoperative Level of Pain Catastrophising in Total Knee Arthroplasty

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Hvidovre University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect. The investigators therefore investigate the effect of Escitalopram as a perioperative analgesic.

Detailed description

Pain is a major problem after TKA, especially in patients with high pain catastrophizing. Newer MR-scan studies indicate that Escitalopram may have an immediate cognitive and emotional effect. Patients with high pain catastrophizing are mentally vulnerable and may be sensitive to the effects of Escitalopram. We therefore investigate the effect of Escitalopram as a perioperative analgesic in this group of patients where the pain problem is pronounced.

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	Escitalopram	Tables with Escitalopram (10 mg), 1 tablet a day for 7 days, starting on the day of surgery
DRUG	Placebo	Placebo tablets, 1 tablet a day for 7 days, starting on the day of surgery

Timeline

• Start date: 2011-09-01
• Primary completion: 2013-04-01
• Completion: 2013-05-01
• First posted: 2011-09-08
• Last updated: 2013-06-05

Locations

3 sites across 1 country: Denmark