NCT01429649

Study of Ablation for the Pulmonary Focal Pure Ground Glass Opacity (pGGO)

A Prospective Study of Ablation of Pulmonary Focal Pure Ground Glass Opacity

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Dongfang Hospital Beijing University of Chinese Medicine · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

With the advent of CT screening for lung cancer, there is an increase in the detection of pulmonary lesions with focal pure ground-glass opacity (pGGO). The pure Ground-glass opacities can be caused by normal expiration, partial filling of air spaces, partial collapse of alveoli, interstitial thickening, inflammation, oedema, fibrosis, and lepidic proliferation of neoplasm. Precise details of the natural history of focal pure GGO are still largely unclear. A number of differential diagnoses are possible, including inflammatory disease, focal scar, atypical adenomatous hyperplasia (AAH), and adenocarcinoma in situ. Some of pGGOs remained stable over a considerable time. A long doubling time for pGGOs is already known. Therefore, the strategy of treatment for focal pure GGO lesions is still undecided. The major issue is whether or not the doctors should treat these patients at all or wait until the first sign of a solid lesion developes which may take many years. The purpose of this study is to determine if the ablation therapy is safe and effective for the pulmonary pGGO.

Conditions

• Pulmonary Lesions

Interventions

Type	Name	Description
PROCEDURE	cryotherapy or radiofrequency ablation	Cryoablation or Radiofrequency ablation is performed under CT image guidance.

Timeline

• Start date: 2011-09-01
• Primary completion: 2014-10-01
• Completion: 2014-12-01
• First posted: 2011-09-07
• Last updated: 2011-09-07

Locations

1 site across 1 country: China