NCT01427985

Influence of Premedication Protocols for Neonatal Endotracheal Intubation on Cerebral Oxygenation

The Influence of Two Different Premedication Protocols for Endotracheal Intubation in Neonates on Cerebral Oxygenation

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Ulm · Academic / Other
• Sex: All
• Age: 44 Weeks
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the influence of premedication drugs Atropin, Fentanyl and Mivacurium and of endotracheal intubation on cerebral oxygenation and cardiac output in term and preterm newborn infants. Two different protocols of premedication are compared.

Detailed description

Influence of the following procedures will be examined: * Application of Atropin * Application of Fentanyl * Application of Mivacurium * possible desaturation and / or bradycardia during intubation attempts * restoration of arterial oxygen saturation and / or heart rate after succesful intubation We aim to examine the change of the following parameters by the use of electrical cardiometry: * stroke volume * cardiac output We compare two different premedication protocols and we evaluate the impact of these protocol on the time needed for intubation and on intubation difficulties .

Conditions

• Newborn
• Preterm
• Intubation

Interventions

Type	Name	Description
DRUG	Atropine, Fentanyl, Mivacurium	1. Atropin 10µg/kg 2. Mivacurium 200µg/kg immediately followed by 3. Fentanyl 2µg/kg
DRUG	Atropine, Fentanyl, Mivacurium	1. Atropin 10µg/kg 2. Fentanyl 2µg/kg, repeat max. two times 3. Mivacurium 200µg/kg

Timeline

• Start date: 2011-06-01
• Primary completion: 2012-07-01
• Completion: 2012-07-01
• First posted: 2011-09-02
• Last updated: 2016-04-06

Locations

1 site across 1 country: Germany