NCT01427647

Inflammatory Response After Colorectal Cancer Surgery

Inflammatory Response Following Colorectal Cancer Surgery Depends on the Type of Anesthesia and Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Universidad Complutense de Madrid · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Laparoscopic technique and epidural anesthesia have been proposed to improve postoperative outcome following colorectal cancer surgery. The investigators hypothesize that the inflammatory response is attenuated by laparoscopic surgery and epidural anesthesia compared to traditional open surgery under general anesthesia.

Detailed description

Patients scheduled for open colorectal cancer surgery were randomly allocated to receive general anesthesia (CON group, n=22) or general anesthesia with thoracic epidural anesthesia (EPI group, n=21). Patients undergoing laparoscopic surgery (LAP group, n=20) composed the third arm of the study. Measurement of perioperative changes in several hormones and cytokines were blinded to group assignment. Primary outcome: Compare simultaneously two types of surgical and anesthesia techniques for colorectal cancer surgery and measure to what extent the stress response is lessened.

Conditions

• Colorectal Cancer

Interventions

Type	Name	Description
PROCEDURE	Laparoscopic technique and thoracic epidural anesthesia	We have compared colorectal cancer surgery under two types of surgical(laparoscopic versus open) and anesthesia (thoracic epidural versus general) techniques

Timeline

• Start date: 2007-06-01
• Primary completion: 2009-05-01
• Completion: 2010-02-01
• First posted: 2011-09-01
• Last updated: 2016-07-22

Locations

1 site across 1 country: Spain