NCT01427335

Calcium for Prevention of Ovarian Hyperstimulation Syndrome

Does Intravenous Calcium Infusion Effectively Prevent OHSS : a Randomised Controlled Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: Female
• Age: 20 Years – 38 Years
• Healthy volunteers: Accepted

Summary

There are many protocols for prevention of ovarian hyperstimulation syndrome, intravenous calcium is a novel protocol. But still there is lack of evidence of it is real effect in prevention of OHSS \& the mechanism of its action is still questionable . In the study the investigators try to search for the evidence for its effect \& the real mechanism for its action.

Detailed description

The study population will be divided into 2groups each containing 100 infertile couples candidate for ICSI. Group (A)active group: administration of 10% Intravenous calcium gluconate 10 ml in 200 mL of physiologic saline on the day of ovum pickup, day 1,day 2, and day 3 after ovum pickup. Intravenous infusion was performed within 30 minutes. Group (B): placebo group: administration of 200 mL of 0.9% saline on the day of ovum pickup, day 1,day 2, and day 3 after ovum pickup. Intravenous infusion was performed within 30 minutes

Conditions

• Ovarian Hyperstimulation Syndrome

Interventions

Type	Name	Description
DRUG	calcium	intravenous infusion of 10 % calcium gluconate 10 mL in 200 mL of physiologic saline on the day of ovum pickup, day 1,day 2, and day 3 after ovum pickup were administered in study group. Intravenous infusion was performed within 30 minutes
DRUG	0.9 % saline	0.9 % saline intravenous infusion

Timeline

• Start date: 2011-10-01
• Primary completion: 2013-09-01
• Completion: 2013-09-01
• First posted: 2011-09-01
• Last updated: 2014-07-09

Locations

1 site across 1 country: Egypt