NCT01427192

Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension

Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension (CSRPH)

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to study the differential short-term effect of nocturnal oxygen, acetazolamide tablets and nocturnal non-invasive positive pressure ventilation on symptoms, exercise capacity and nocturnal breathing disturbances in subjects with pulmonary hypertension and sleep related breathing disorders * Trial with medicinal product

Conditions

• Pulmonary Hypertension
• Breathing-Related Sleep Disorder

Interventions

Type	Name	Description
DRUG	acetazolamide	250 mg bid
OTHER	Supplemental oxygen	Oxygen deliverded by nasal cannula
PROCEDURE	Non-invasive ventilation	Bi-level non-invasive ventilation via nasal mask
OTHER	Room air	Room air applied via sham oxygen concentrator
DRUG	Placebo tablet	Placebo tablet (Mannitol) similar to acetazolamide

Timeline

• Start date: 2010-11-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2011-09-01
• Last updated: 2012-12-12

Locations

1 site across 1 country: Switzerland