NCT01426945

Protein Expression in Samples From Young Patients With Rhabdomyosarcoma

Evaluating Candidate Protein Expression in Human Rhabdomyosarcoma (RMS)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 77 (estimated)
• Sponsor: Children's Oncology Group · Network
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies protein expression in samples from young patients with rhabdomyosarcoma.

Detailed description

OBJECTIVES: * To measure the protein expression of candidate proteins in human rhabdomyosarcoma (RMS) tumor samples. OUTLINE: Archived tumor tissue samples are analyzed for protein expression (i.e., Notch1, Hey1, FGFR4, and Sp1) by IHC techniques and standard commercially available antibodies. Candidate proteins are then correlated with each patient age, gender, rhabdomyosarcoma (RMS) tumor stage, and RMS tumor subtype.

Conditions

• Sarcoma

Interventions

Type	Name	Description
GENETIC	protein expression analysis
OTHER	immunohistochemistry staining method
OTHER	laboratory biomarker analysis

Timeline

• Start date: 2011-11-01
• Primary completion: 2016-05-01
• First posted: 2011-09-01
• Last updated: 2016-05-18